INFLUÊNCIA DO TEMPO DE REVESTIMENTO NO TAMANHO E ESTABILIDADE DE NANOPARTICULAS DE MAGNETITA PARA TRATAMENTOS DE HIPERTERMIA MAGNÉTICA
INFLUENCE OF THE COATING TIME ON THE SIZE AND STABILIZATION OF MAGNETITE NANOPARTICLES FOR MAGNETIC HYPERTHERMIA TREATMENT
Mara Carolina do Carmo Paresque, Elizabeth Mendes de Oliveira, José Adilson de Castro
Resumo
Em tratamentos de hipertermia magnética, as etapas de produção e revestimento das nanopartículas magnéticas são de fundamental importância para sua funcionalidade e eficiência durante a dinâmica do tratamento. O método de coprecipitação vem sendo utilizado para sintetizar nanopartículas de magnetita (Fe3 O4 ), largamente utilizadas neste tratamento. As mesmas foram recobertas com uma camada polimérica de polietilenoglicol (PEG) visando prevenir a oxidação do núcleo, permitir sua dispersão em água, aumentar sua estabilidade coloidal, bem como evitar a aglomeração das nanopartículas. Foram realizadas cinco sínteses, cada uma delas com tempos da etapa de revestimento das nanopartículas de 10, 20, 30, 50 e 60 minutos, respectivamente. Foram avaliadas a influência do tempo de revestimento no tamanho das partículas utilizando Nanoparticle Traking Analysis (NTA) e a estabilidade do revestimento por TGA/DSC. As nanopartículas revestidas apresentaram diâmetros médios na faixa de 31 a 40 nm. Analises no TGA/DSC permitiram observar a presença de uma camada adsorvida na superfície do núcleo magnético, bem como a eficácia do polietilenoglicol na proteção do núcleo de magnetita.
Palavras-chave
Abstract
In the magnetic hyperthermia treatment the nanoparticles production and coating procedure are fundamental for the efficiency during the treatment dynamics. The coprecipitation method has been used to synthesize magnetite nanoparticles (Fe3O4). They were coated with a polyethylene glycol (PEG) polymer layer to prevent the oxidation of the magnetic core, to allow dispersion of the nanoparticles in water, to increase their colloidal stability, as well as to avoid the agglomeration of the particles. Five syntheses were carried out with the coating stage of the particles times of 10, 20, 30, 50 and 60 minutes, aiming to evaluate the influence of coating time on the final nanoparticle size using Nanoparticle Traking Analysis (NTA) measurements and coating stability using TGA/DSC techniques. The results indicated that average diameters in the range of 31 to 40 nm were obtained. TGA/DSC results indicated that a stable adsorbed layer on the surface of the magnetic core promoted by the polyethylene glycol is effective in the protection of the magnetite nucleus.
Keywords
Referências
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